R-6890 (Spirochlorphine)

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Names:	Spirochlorphine R6890, R-6890 R-6890
IUPAC name:	8-[1-(4-chlorophenyl)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Substance group:	Orphine analogues
Effect group:	Synthetic opioids
Structure:
CAS Number:	3222-88-6
InChI:	InChI=1S/C21H24ClN3O/c1-16(17-7-9-18(22)10-8-17)24-13-11-21(12-14-24)20(26)23-15-25(21)19-5-3-2-4-6-19/h2-10,16H,11-15H2,1H3,(H,23,26)
InChI Key:	KFEYPBZJPJJRFX-UHFFFAOYSA-N
SMILES:	O=C1C(CCN2C(C(C=C3)=CC=C3Cl)C)(CC2)N(C4=CC=CC=C4)CN1
Molecular Formula:	C₂₁H₂₄ClN₃O
Molecular Weight:	369.8878 g/mol

Buy Spirochlorphine online Europe.R6890, sometimes known as spirochlorphine, is an opioid analgesic and a member of the spiropiperidine family of agents.^[1]^[2]^[3] The first known mention of this compound was in 1977.^[4] Other examples of agents from this class are Ro64-6198 and Ro65-6570. Brorphine also has a similar structure.

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A precursor chemical used in the synthesis of R6890 is 1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one (also known as spirodecanone), which is used in the synthesis of other drugs including spirilene, fluspirilene, spiramide, spiperone, RP-23618, spiroxatrine, L008716 and R5260.

Pharmacology

The pharmacology of R6890 is described as a nociceptin receptor (NOP) agonist, although R6890 retains significant affinity at the mu opioid receptor.^[5] R6890 has affinities (K_i values) of 4, 75, and 10 nM for the mu, delta, and the total opioid receptor population, respectively.^[6]

Formal Name

8-[1-(4-chlorophenyl)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

CAS Number

3222-88-6

Molecular Formula

C₂₁H₂₄ClN₃O

Formula Weight

369.9

Purity

≥98%

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