Medetomidine Powder

Buy Medetomidine CAS 86347-15-1 online.Medetomidine is a veterinary anesthetic medication with potent sedative effects. As of December 2025, it is an emerging illicit drug adulterant.^[4][5]

It is a racemic mixture of two stereoisomers, levomedetomidine and dexmedetomidine, the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist. Effects can be reversed using atipamezole.

It was developed by Orion Pharma.^[6] It is approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. Starting in 2022 medetomidine has been detected in the US in samples of illicit drugs and associated with overdoses.

The free base form of medetomidine is sold as an antifouling substance for marine paints.^[7]

Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine.^[8] The latter causes the alpha 2- adrenergic agonist effects.^[9]

Medetomidine is an α₂-adrenergic receptor agonist that binds at a ratio of 1620:1 with imidazoline receptor activity.^[10]

Medetomidine is metabolised in the liver via hydroxylation.^[10]

Medetomidine has been found as a component in street drug mixtures in the US starting in 2022,^[8][4] containing synthetic opioids in a similar manner as xylazine–fentanyl, such mixtures have been nicknamed “tranq” (short for tranquilizer); medetomidine on its own has been nicknamed “rhino tranq”.^[19] The combination of α2 adrenergic agonists with opioids are believed to greatly increase the sedative effects of each drug, which some drug users may perceive as a better or more potent product. The Center for Forensic Science Research and Education (CFSRE) first identified a synthetic opioid blend containing fentanyl and medetomidine sold in Maryland in July, 2022. Additional detections in late 2023 and early 2024 found similar medetomidine mixtures in Missouri, Colorado, Pennsylvania, California, Maryland, and New York found in both drug material and the blood of patients experiencing overdoses.^{[20][21][22][23][4][24]}