Buy phenibut powder online Europe.Phenibut, sold under the brand name Anvifen among others,^[1] is a central nervous system (CNS) depressant with anxiolytic effects, and is used to treat anxiety, insomnia, and for a variety of other indications.^[5] It is usually taken orally (swallowed by mouth), but may be given intravenously.^[6]^[5]

Side effects of phenibut can include sedation, sleepiness, nausea, irritability, agitation, dizziness, euphoria, and sometimes headache, among others.^[6]^[7] Overdose of phenibut can produce marked central nervous system depression including unconsciousness.^[6]^[7] The medication is structurally related to the neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue.^[5] Phenibut is thought to act as a GABA_B receptor agonist, similarly to baclofen and γ-hydroxybutyrate (GHB).^[5] However, at low concentrations, phenibut mildly increases the concentration of dopamine in the brain, providing stimulatory effects in addition to the anxiolysis.^[8]

Phenibut was developed in the Soviet Union and was introduced for medical use in the 1960s.^[5] Today, it is marketed for medical use in Russia, Ukraine, Belarus, Kazakhstan, and Latvia.^[5] The medication is not approved for clinical use in the United States and most of Europe, but it is sold on the Internet as a supplement and purported nootropic.^[3]^[9] Phenibut has been used recreationally and can produce euphoria as well as addiction, dependence, and withdrawal.^[3] It is a controlled substance in Australia, and it has been suggested that its legal status should be reconsidered in Europe as well.^[3] In Germany, phenibut is not approved as a drug and, as a food supplement, is controlled under the German New Psychoactive Substances Act.^[10]

In a 2023 assessment, the U.S. Food and Drug Administration (FDA) determined that phenibut does not meet the definition of a dietary ingredient, thereby making phenibut supplement products misbranded and illegal for marketing.^[11] FDA warning letters had been issued to supplement manufacturers marketing phenibut products as adulterated.^[12]

Medical uses

Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia).^[5]^[6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière’s disease, dizziness, for the prevention of motion sickness, and for the prevention of anxiety before or after surgical procedures or painful diagnostic tests.^[6]^[5]

Available forms

Phenibut is available as a medication in the form of 250 mg or 500 mg tablets for oral administration and as a solution at a concentration of 10 mg/mL for infusion.^[6]^[7]^[13] In the US, dietary supplements labeled as containing phenibut have been found to contain zero to greater than 1,100 mg of phenibut per serving.^[9]

Uses

What is phenibut used for?

Phenibut is used for various purposes, but its benefits are not well defined and it may cause serious side effects. Some reasons that people use phenibut include the following.

Substance use disorder or alcohol use disorder
Anxiety
Depression
Posttraumatic stress disorder (PTSD)
Trouble sleeping (insomnia)

Note: Phenibut is not approved by the FDA for any use. The FDA also does not consider phenibut to be a legal dietary ingredient in the U.S. Learn more about the legal status of phenibut here.

How does phenibut work (mechanism of action)?

Phenibut is a psychoactive substance that is available as a prescription medicine in some countries. In the U.S., phenibut is not a legal ingredient and cannot be legally sold in any products. But it may still be available for purchase online.

Phenibut is similar to a natural brain chemical called gamma-aminobutyric acid (GABA). Your brain and nervous system contain GABA receptors. Phenibut can bind to these receptors, causing the signals sent by your brain and nerves to slow down. This has led to interest in taking phenibut for issues such as anxiety and trouble sleeping. But the benefits of phenibut for any use are not well defined, and many people who use phenibut develop a tolerance to its effects. This means that they need to keep increasing their dose to notice any benefits. Some people may also develop physical dependence on phenibut. See the Side Effects section for more information.

How should I store phenibut?

You should store phenibut according to the product label. Most dietary supplements should be kept in a cool, dry location that is out of the reach of children and pets and not in direct sunlight.