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5-fluoro MDMB-PICA buy online.5F-MDMB-PICA (MDMB-5F-PICA^[2]) is a designer drug and synthetic cannabinoid.^{[3][4][5][6][7]} In 2018, it was the fifth-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration.^[8]

5F-MDMB-PICA is a potent agonist of both the CB₁ receptor and the CB₂ receptor with EC₅₀ values of 0.45 nM and 7.4 nM, respectively.^[9]

In the United States, 5F-MDMB-PICA was temporarily emergency scheduled by the DEA in 2019.^[10] In December 2019, the UNODC announced scheduling recommendations placing 5F-MDMB-PICA into Schedule II.^[11] In the United States 5F-MDMB-PICA was made a permanent Schedule I Controlled Substance nationwide on April 7, 2022.^[12]

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